Ingredients & Research
Our most frequently asked question is “How does this product work?”
Understanding how Vitiligo Organics works requires an appreciation of how the skin is impacted by vitiligo, as well as the attributes of the medicinal ingredients both independently and in combination.
Skin Structure & Function
The Skin as an Organ
Functional Skin Cells
Keratinocytes (Barrier cells),
Melanocytes (Pigment Cells),
Langerhans cells (Immune cells), and
Merkel cells (Sensory).
Frequently Asked Questions
Keratinocytes, Melanocytes & Melanin
1. Langerhans Cell
3. Melanin Granules
Loss of Melanocytes
Keratinocytes and melanocytes are necessary for normal, healthy skin function and colour. Disruption to one or both of these cell types can result in imbalance and a cascade in stresses and dysfunction. Unlike keratinocytes, the natural renewal of melanocytes is rare, and as a consequence, any loss in function or cell death leads not only to prolonged periods of depigmentation but also biochemical skin dysfunction.
Vitiligo is an autoimmune disease with highly visible symptoms of skin depigmentation. The depigmentation results from melanocytes loss. Langerhans cells (immune cells) are thought to play a major immunological role in vitiligo(21). Imbalance in the normal interactions between keratinocytes, melanocytes, and Langerhans cells is thought to initiate the depigmentation.
Frequently Asked Questions
It is known that a multitude of natural biochemical pathways are disrupted when vitiligo is diagnosed, including
- redox imbalance,
- inflammation and
- immune dysfunction
In some cases, this is accompanied by in addition to an influx of Langerhans cells(24), thought to be involved in active spreading vitiligo(19).
About Vitiligo Organics
Suppressing immune cells(25) thought to be active in spreading vitiligo within the skin(30), and Quenching excess hydrogen peroxide, a by-product of melanin production that contributes to melanocyte death, and Promoting the growth of melanocytes and Stimulating melanin production
Working Mechanism of Active Ingredients
Each of the active ingredients has different activities, each targeting complementary outcomes, providing a comprehensive approach to normalising skin function and pigmentation.
Cullen Corylifolium Purified forms of this substance are used as part of conventional photochemotherapy (30). Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and Importantly, it suppresses the Langerhans cells(25). limiting cellular damage and decline by quenching reactive oxygen species; suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and promoting melanin production and normalising immune responses(29)
Berberis Vulgaris Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and Promoting the renewal and development of melanocytes, and for stimulating melanin production and Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
Nigella Sativa Seeds It has potent antioxidant effects that help to suppress oxidative stress, and It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.
Virgin Coconut Oil Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and Are effective at reducing hydrogen-peroxide mitigated cell death (15).
Let's Ask Us Questions
Cullen Corylifolium Purified forms of this substance are used as part of conventional photochemotherapy (30). Importantly, it suppresses the Langerhans cells(25). limiting cellular damage and decline by quenching reactive oxygen species; promoting melanin production and normalising immune responses(29)
Berberis Vulgaris Promoting the renewal and development of melanocytes, and for stimulating melanin production and Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
Nigella Sativa Seeds
Nigella Sativa Seeds It has potent antioxidant effects that help to suppress oxidative stress, and
Virgin Coconut Oil
Virgin Coconut Oil Are effective at reducing hydrogen-peroxide mitigated cell death (15).
Why Try Vitiligo Organics?
Frequently Asked Questions
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