Ingrediënten & Onderzoek

De meerderheid van de vitiligopatiënten denkt dat er niets aan vitiligo kan worden gedaan.
Onze meest gestelde vraag is "Hoe werkt dit product?".
Om te begrijpen hoe Vitiligo Organics werkt, moet je begrijpen hoe de huid wordt beïnvloed door vitiligo, evenals de eigenschappen van de medicinale ingrediënten, zowel afzonderlijk als in combinatie.

Huidstructuur & Functie

De huid als orgaan
De huid als orgaan  De huid is een complex orgaan dat zowel fysieke bescherming biedt als de temperatuur regelt, tastzin mogelijk maakt, UV-licht absorbeert (en reflecteert) en als eerste verdedigingslinie van het immuunsysteem fungeert.

De huid is een complex orgaan. Onze huid is verdeeld in verschillende lagen met elk hun eigen functionele elementen. In een gezonde huid werken al deze elementen samen om ons te beschermen.
Functionele huidcellen
De buitenste laag van de huid wordt de opperhuid genoemd. Deze bestaat uit verschillende lagen en bevat vier belangrijke celtypen
  • Keratinocyten (barrièrecellen),
  • Melanocyten (pigmentcellen),
  • Langerhanscellen (immuuncellen) en
  • Merkelcellen (zintuigcellen).
Functional Skin Cells
Huidcellen worden bij elkaar gehouden door desmosomen en de cellen worden beschermd en verstevigd door keratohyaline en lamellaire granules.

Keratinocytes, Melanocytes & Melanin

Keratinocyten vormen ~ 90% van de celpopulatie. cellen. Keratinocyten ontwikkelen zich vanuit de onderste of basale laag van de epidermis en migreren dan omhoog over een periode van ongeveer vier weken naar het buitenoppervlak (stratum corneum) waar ze worden afgestoten. Zowel keratinocyten en melanocyten produceren belangrijke eiwitten die de groei en vermenigvuldiging van melanocyten en de productie van melanine regelen.
De melanocyt is een zeer gespecialiseerde, bijzonder lang levende cel die melanine (natuurlijk huidpigment/kleurstof) produceert uit het aminozuur tyrosine. pigment/kleur) produceert uit het aminozuur tyrosine. Binnen de onderste laag van van de opperhuid zijn er ongeveer 10x meer keratinocyten dan melanocyten; Er zijn echter nog steeds ongeveer 1200 melanocyten per mm2 huid, onafhankelijk van ras. De dichtheid van melanocyten in de huid hangt voornamelijk af van blootstelling aan ultraviolette straling en factoren die worden afgescheiden door keratinocyten en fibroblasten (functionele cellen in de dermis, de huidlaag onder de opperhuid).
Melanine gemaakt in de melanocyt wordt overgedragen aan basale keratinocyten, waarbij één melanocyt tot wel 36 keratinocyten. Melanine heeft veel eigenschappen die gunstig zijn voor het lichaam, zoals lichaam, waaronder absorptie en verstrooiing van UV-licht, vrije radicalen vangen, redoxbalans en ionenopslag. De melanocyt scheidt ook verschillende signaalmoleculen die niet alleen gericht zijn op keratinocyten, maar ook op belangrijke huidcellen van het immuunsysteem.
Keratinocytes Melanocytes Melanin

1. Langerhanscel

Modulatie van de adaptieve immuunrespons

2. Keratinocyt

Primaire cellulaire componenten van de epidermale barrière

3. Melanine korrels

Bestaande uit melanosomen voor ultraviolette bescherming

4. Melanocyt

De oorsprong van de melanineproductie

5. Lederhuid

Betrokkenheid bij de immuunrespons, ontstekingsschade en wondgenezing

Loss of Melanocytes

Keratinocyten en melanocyten zijn noodzakelijk voor een normale, gezonde huid functie en kleur. Verstoring van één of beide van deze celtypen kan leiden tot onbalans en een cascade van spanningen en disfunctie. In tegenstelling tot keratinocyten is de natuurlijke vernieuwing van melanocyten zeldzaam. Bijgevolg leidt elk functieverlies of celdood niet alleen tot lange perioden van depigmentatie, maar ook tot biochemische disfunctie.
Loss Of Melanocytes

Over Vitiligo

Vitiligo is een auto-immuunziekte met zeer zichtbare symptomen van depigmentatie. De depigmentatie is het gevolg van het verlies van melanocyten. Van Langerhanscellen (immuuncellen) wordt gedacht dat ze een belangrijke immunologische rol bij vitiligo(21). Onbalans in de normale interacties tussen keratinocyten, melanocyten en Langerhanscellen zou de de depigmentatie in gang zet.
About Vitiligo

Vitiligo Pathogenesis

Het is bekend dat bij de diagnose van vitiligo een groot aantal natuurlijke biochemische processen wordt verstoord, waaronder

  • redoxverstoring,
  • ontsteking en
  • immuundisfunctie
. In sommige gevallen gaat dit gepaard met naast een instroom van Langerhanscellen(24), waarvan gedacht wordt dat ze betrokken zijn bij actieve verspreiding van vitiligo(19).
Vitiligo Pathogenesis

Over Vitiligo Organics

Net als Net als andere moderne, farmaceutische preparaten worden dit geneesmiddel en zijn actieve ondersteund door de wetenschap, waaronder verschillende klinische proeven. 

In tegenstelling tot sommige andere producten is het ontworpen voor een brede en veelzijdige aanpak van verschillende, belangrijke aspecten van de ziekte aan te pakken, waaronder.
  • Onderdrukking van immuuncellen(25) waarvan wordt vermoed dat ze actief zijn bij de verspreiding van vitiligo in de huid(30), en
  • Het afzwakken van overtollig waterstofperoxide, een bijproduct van de melanineproductie dat bijdraagt tot het afsterven van melanocyten, en
  • Bevorderen van de groei van melanocyten en
  • Stimuleren van de melanineproductie

Deze gecombineerde activiteiten kunnen helpen de huidbiologie te normaliseren en een normale, gezonde pigmentatie te herstellen.

Werkingsmechanisme van actieve ingrediënten

Elk van de actieve ingrediënten heeft verschillende activiteiten, elk gericht op complementaire resultaten, waardoor een allesomvattende aanpak wordt geboden voor het normaliseren van de huidfunctie en pigmentatie.
Cullen Corylifolium
Berberis Vulgaris
Nigella Sativa Seeds
Virgin Coconut Oil
Vitiligo Organics Natural Ingredients - Cullen Corylifolium Whole Plant

Cullen Corylifolium

Psoralenen is het belangrijkste bioactieve bestanddeel in de gedroogde vruchten van Cullen Corylifolium. Medische professionals herkennen deze stof als de basis van enkele van de meest effectieve farmacologische interventies voor vitiligo (21).

  • Gezuiverde vormen van deze stof worden gebruikt als onderdeel van conventionele fotochemotherapie (30).
  • Psoralen heeft een tijdelijk fotosensibiliserend effect(23), bevordert de melanineverspreiding(2) en waardoor het aantal melanocyten toeneemt(24) en
  • belangrijk is dat het de Langerhanscellen onderdrukt(25).
Psoralenen beïnvloedt, net als veel andere biologisch actieve Psoralenen beïnvloedt ook een aantal biochemische processen. De goed gekarakteriseerde acties zijn onder andere(28)
  • het beperken van celbeschadiging en achteruitgang door het onderdrukken van reactieve zuurstofsoorten;
  • het onderdrukken van ontstekingen door interactie met pro-inflammatoire cytokinen en het onderdrukken van ontstekingssignaleringsprocessen, en
  • het bevorderen van de melanineproductie en
  • het normaliseren van immuunreacties(29)

Deze eigenschappen alleen worden vaak voldoende geacht voldoende voor een professionele behandeling van vitiligo. De activiteit van dit ingrediënt wordt aangevuld door andere, even krachtige stoffen.

Vitiligo Organics Natural Ingredients - Berberis Vulgaris Root Bark

Berberis Vulgaris

De wortel van de berberis (Berberis vulgaris) wordt al duizenden jaren gebruikt(5) en in veel verschillende traditionele geneeswijzen als middel tegen vitiligo. De moderne wetenschap begint nu te ontcijferen hoe de schors van de Barberrywortel schors de gezondheid van de huid beïnvloedt en een normalere werking bevordert. De schors van de De wortelschors bevat van nature berberine in concentraties tot ~7-12%(8). tot ~7-12%(8).
Berberine is een krachtige fytochemische stof die een breed therapeutische voordelen heeft(16), waaronder immuunmodulerende en ontstekingsremmende activiteiten(34).

Het lijkt vooral een rol te spelen in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.
Vitiligo Organics Natural Ingredients - Nigella Vulgaris Root Bark

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.
A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.
An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.
As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.
Vitiligo Organics Natural Ingredients - Certified Organic Coconut Oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil
  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Cullen Corylifolium

cullen-corylifolium-in

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

  • Purified forms of this substance are used as part of conventional photochemotherapy (30).
  • Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
  • Importantly, it suppresses the Langerhans cells(25).
Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)
  • limiting cellular damage and decline by quenching reactive oxygen species;
  • suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
  • promoting melanin production and
  • normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Berberis Vulgaris

Berberis-Vulgaris-root

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).

Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.

Nigella Sativa Seeds

Nigella-seeds

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.

A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.

An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.

As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.

Virgin Coconut Oil

coconut-oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil

  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Vitiligo Organics

Why Try Vitiligo Organics?

Vitiligo Organics is well known and trusted vitiligo medicine for over a decade. It is listed in the Australian Register of Therapeutic Goods, having satisfied the requirements for purity, quality, safety, and effectiveness. It is manufactured in TGA licensed facility, by qualified and authorised professionals, using ingredients and processes that have been validated and verified. TGA is a similar regulatory authority in Australia as FDA in the United States.
Every aspect of the Manufacturing and Quality Control is carefully managed, from the chemical fingerprint identity verification of all the herbs, through to the manufacture, product testing and packaging processes. Following the latest science, we source every ingredient for the highest possible quality and efficacy. No compromise to the quality and unique scientific formulation makes Vitiligo Organics extremely effective.
Vitiligo Organics is one of very few, authentic medicines that takes a comprehensive, multifaceted science-based approach remedying the symptoms of vitiligo; and readdressing what are considered to be some of the underlying causes and consequences of the disease. We don’t claim to have all the answers, but we sincerely believe that this product can and does help reversing the symptoms of vitiligo; and that both tradition and modern scientific evidence support its use.
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Bibliography

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