재료 및 연구

대부분의 백반증 환자들은 백반증에 대해 할 수 있는 치료법이 없다고 생각합니다.
가장 자주 묻는 질문은 "이 제품은 어떻게 작동하나요?"입니다.
백반증 오가닉스의 작동 원리를 이해하려면 다음과 같은 이해가 필요합니다. 백반증에 의해 피부가 어떻게 영향을 받는지, 그리고 백반증에 사용되는 약용 성분의 속성에 대한 이해가 필요합니다.

피부 구조 및 기능

기관으로서의 피부
기관으로서의 피부 피부는 신체 보호는 물론 체온 조절, 촉각, 자외선 흡수(및 반사), 면역 체계의 첫 번째 방어선 역할을 하는 복잡한 기관입니다.

피부는 복잡한 기관입니다. 우리의 피부는 여러 층으로 나뉘며, 각 층에는 고유한 기능적 요소가 포함되어 있습니다. 건강한 피부에서는 이러한 모든 요소가 응집력 있게 작용하여 피부를 보호합니다.
기능성 피부 세포
피부의 가장 바깥층을 표피라고 하며, 여러 층으로 구성되어 있고 네 가지 주요 세포 유형
  • 케라티노세포(장벽 세포),
  • 멜라닌세포(색소 세포)를 포함하고 있습니다,
  • 랑게르한스 세포(면역 세포),
  • 메르켈 세포(감각 세포).
Functional Skin Cells
피부 세포는 데스모좀에 의해 서로 결합되어 있으며, 케라토히알린과 라멜라 과립에 의해 세포가 보호되고 강화됩니다.
Keratinocytes, Melanocytes & Melanin
각질 세포는 전체 세포의 약 90%를 차지합니다. 세포의 약 90%를 차지합니다. 각질 세포는 표피의 바닥 또는 기저층에서 발생하여 표피의 바닥 또는 기저층에서 발달한 후 약 4주 동안 위쪽으로 이동하여 바깥쪽 표면(각질층)으로 이동하여 탈락합니다. 각질 세포와 멜라닌 세포 모두 각질 세포와 멜라닌 세포는 모두 멜라닌 세포의 성장과 증식, 멜라닌 생성을 조절하는 핵심 단백질을 생산합니다. 멜라닌 세포의 성장과 증식, 그리고 멜라닌 생성을 조절하는 핵심 단백질을 생산합니다.
멜라닌 세포는 고도로 전문화된 세포입니다, 특히 수명이 긴 세포로, 아미노산 티로신으로부터 멜라닌(천연 피부의 색소/색소)를 생성하는 아미노산 티로신에서 생성됩니다. 표피의 아래층에는 표피 하층에는 각질 세포가 멜라닌 세포보다 약 10배 더 많습니다; 하지만 여전히 피부 1㎡당 약 1200개의 멜라닌 세포가 존재합니다, 인종과 무관합니다. 피부의 멜라닌 세포 밀도는 주로 주로 자외선에 노출되고 각질 세포와 섬유아세포(진피에서 발견되는 기능성 세포, 표피 아래 피부 층인 표피 아래 피부층)에서 발견되는 기능 세포).
멜라닌 세포에서 생성된 멜라닌은 기저 각질 세포로 전달되며, 하나의 멜라닌 세포는 최대 36개의 각질 세포를 공급합니다. 멜라닌은 신체에 유익한 여러 가지 특성을 가지고 있습니다. 자외선 흡수 및 산란, 자유 라디칼 제거, 산화 환원 균형 및 이온 저장 등 신체에 유익한 특성을 가지고 있습니다. 멜라닌 세포는 또한 각질 세포뿐만 아니라 중요한 면역 세포를 표적으로 하는 중요한 면역계 피부 세포를 표적으로 하는 여러 신호 분자를 분비합니다.
Keratinocytes Melanocytes Melanin

1. 랑게르한스 세포

적응 면역 반응의 조절

2. 각질 세포

표피 장벽의 주요 세포 구성 요소

3. 멜라닌 과립

자외선 차단을 위한 멜라노좀 성분 함유

4. 멜라닌 세포

멜라닌 생성의 기원

5. Dermis

면역 반응, 염증성 손상 및 상처 치유에 관여합니다.
Loss of Melanocytes
각질 세포와 멜라닌 세포는 정상적이고 건강한 피부를 위해 필요합니다. 기능과 색을 유지하는 데 필요합니다. 이러한 세포 유형 중 하나 또는 두 가지 모두에 장애가 생기면 불균형을 초래하고 스트레스와 기능 장애가 연쇄적으로 발생할 수 있습니다. 각질 세포와 달리 각질 세포와 달리 멜라닌 세포의 자연 재생은 드물기 때문에 결과적으로 기능 상실이나 세포 사멸로 이어집니다. 장기간의 탈색뿐만 아니라 생화학적 피부 기능 장애 기능 장애로 이어집니다.
Loss Of Melanocytes

백반증 정보

백반증은 눈에 잘 띄는 피부 색소 침착 증상을 보이는 자가 면역 질환입니다. 색소 침착. 색소 침착은 멜라닌 세포의 손실로 인해 발생합니다. 랑게르한스 세포(면역 세포)는 백반증에서 주요한 백반증에서 면역학적 역할을 하는 것으로 알려져 있습니다(21). 정상적인 상호작용의 불균형 각질 세포, 멜라닌 세포, 랑게르한스 세포 사이의 정상적인 상호작용의 불균형이 탈색이 시작되는 것으로 생각됩니다.
About Vitiligo
Vitiligo Pathogenesis

백반증이 진단되면 다음과 같은 다양한 자연 생화학적 경로가 중단되는 것으로 알려져 있습니다.

  • 산화 환원 불균형,
  • 염증 및
  • 면역 기능 장애
어떤 경우에는 다음과 같은 유입이 동반됩니다. 랑게르한스 세포(24), 활발한 확산에 관여하는 것으로 생각됨. 백반증(19).
Vitiligo Pathogenesis

비티고 오가닉 소개

마찬가지로 다른 현대 의약품과 마찬가지로, 이 약과 그 활성 성분은 여러 인체 임상 시험을 포함한 과학적 실험을 포함한 과학적 근거가 있습니다.

다른 제품과는 다르게 광범위하고 다각적인 접근 방식을 제공하도록 설계되었습니다. 다음과 같은 질병의 여러 가지 주요 측면을 해결하도록 설계되었습니다.
  • 피부 내 백반증 확산에 관여하는 것으로 알려진 면역세포(25) 억제(30) 및
  • 멜라닌 생성의 부산물인 과산화수소를 억제하여 멜라닌 세포 사멸에 기여하는 것으로 알려져 있습니다, 그리고
  • 멜라닌 세포의 성장 촉진 및
  • 멜라닌 생성 촉진

이러한 복합 작용은 피부 생리를 정상화하여 정상적이고 건강한 색소를 회복하는 데 도움이 될 수 있습니다.

활성 성분의 작용 메커니즘

각각의 활성 성분은 서로 다른 작용을 하며 상호 보완적인 결과를 목표로 하여 피부 기능과 색소 침착을 정상화하기 위한 포괄적인 접근 방식을 제공합니다.
Cullen Corylifolium
Berberis Vulgaris
Nigella Sativa Seeds
Virgin Coconut Oil
Vitiligo Organics Natural Ingredients - Cullen Corylifolium Whole Plant

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

  • Purified forms of this substance are used as part of conventional photochemotherapy (30).
  • Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
  • Importantly, it suppresses the Langerhans cells(25).
Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)
  • limiting cellular damage and decline by quenching reactive oxygen species;
  • suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
  • promoting melanin production and
  • normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Vitiligo Organics Natural Ingredients - Berberis Vulgaris Root Bark

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).
Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.
Vitiligo Organics Natural Ingredients - Nigella Vulgaris Root Bark

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.
A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.
An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.
As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.
Vitiligo Organics Natural Ingredients - Certified Organic Coconut Oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil
  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Cullen Corylifolium
cullen-corylifolium-in

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

  • Purified forms of this substance are used as part of conventional photochemotherapy (30).
  • Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
  • Importantly, it suppresses the Langerhans cells(25).
Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)
  • limiting cellular damage and decline by quenching reactive oxygen species;
  • suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
  • promoting melanin production and
  • normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Berberis Vulgaris
Berberis-Vulgaris-root

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).

Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.
Nigella Sativa Seeds
Nigella-seeds

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.

A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.

An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.

As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.

Virgin Coconut Oil
coconut-oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil

  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Vitiligo Organics

Why Try Vitiligo Organics?

Vitiligo Organics is well known and trusted vitiligo medicine for over a decade. It is listed in the Australian Register of Therapeutic Goods, having satisfied the requirements for purity, quality, safety, and effectiveness. It is manufactured in TGA licensed facility, by qualified and authorised professionals, using ingredients and processes that have been validated and verified. TGA is a similar regulatory authority in Australia as FDA in the United States.
Every aspect of the Manufacturing and Quality Control is carefully managed, from the chemical fingerprint identity verification of all the herbs, through to the manufacture, product testing and packaging processes. Following the latest science, we source every ingredient for the highest possible quality and efficacy. No compromise to the quality and unique scientific formulation makes Vitiligo Organics extremely effective.
Vitiligo Organics is one of very few, authentic medicines that takes a comprehensive, multifaceted science-based approach remedying the symptoms of vitiligo; and readdressing what are considered to be some of the underlying causes and consequences of the disease. We don’t claim to have all the answers, but we sincerely believe that this product can and does help reversing the symptoms of vitiligo; and that both tradition and modern scientific evidence support its use.
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Bibliography

1: Ali Current Challenges in Understanding the Story of Skin Pigmentation — Bridging the Morpho-Anatomical and Functional Aspects of Mammalian Melanocytes Chapter 10 Muscle Cell and Tissue doi.org/10.5772/60714
2: Ali (2011) 어류의 시험관 내 반응 동결 건조 된 동결 건조 추출물에 대한 멜라닌 세포 및 순수한 소랄렌, 제약 생물학, 2011; 49(4): 422-427
3:알리 (2015) 베르베린으로 인한 피부 미백 활성의 베르베린에 의한 피부 흑화 활동의 초 구조적 측면 이해 두꺼비, 부포 멜라노스틱투스, 멜라노포어 J 마이크로 울트라스트럭트. 2015 Oct-Dec; 3(4): 210-219.
4: 니겔라 사티바의 알자브레 피부과 효과, 피부과 및 피부과 수술 저널 19
5: Arayne 외; 베르베리스 이야기: 테라퓨틱스 팩의 베르베리스 벌가리스. J. Pharm. Sci., 2007, Vol.20(1), 83-92
6: 아민 블랙 커민(니겔라 사티바) 및 그 효능 활성 성분인 티모퀴논: 진통 및 항염증 효과 Planta Med 2016; 82: 8-16
7: 항산화 방어의 변화 시스템 및 다양한 농도에 따른 단백질 발현의 변화 다양한 농도에 따른 단백질 발현의 변화, Acta Physiol Plant (2015) 37:1707
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