Bahan & Penyelidikan

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Majoriti penderita vitiligo percaya tiada apa yang boleh dilakukan untuk vitiligo.
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Memahami bagaimana kerja organik vitiligo memerlukan penghargaan bagaimana kulit dipengaruhi oleh vitiligo, serta sifat -sifat bahan -bahan ubat -ubatan secara bebas dan digabungkan.

Struktur & Fungsi Kulit

The Skin as an Organ

The skin is a complex organ, providing physical protection as well as controlling temperature, permitting touch sensation, absorbing (and reflecting) UV light and acting as the first line of defence in the immune system.

The skin is a complex organ, Our skin is divided into several layers, each including its own functional elements. In healthy skin, all of these elements work cohesively to protect us.

Functional Skin Cells

The outermost layer of the skin is called the epidermis, it consists of several layers and contains four major cell types

Keratinocytes (Barrier cells),
Melanocytes (Pigment Cells),
Langerhans cells (Immune cells), and
Merkel cells (Sensory).

Skin cells are held together by desmosomes, and the cells are protected and fortified by keratohyalin and lamellar granules.

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Keratinocytes, Melanocytes & Melanin

Keratinocytes make up ~ 90% of the population of cells. Keratinocytes develop from the bottom or basal layer of the epidermis and then migrate upwards over a period of about four weeks to the outer surface (stratum corneum) where they are shed. Both keratinocytes and melanocytes produce key proteins that regulate the growth, and multiplication of melanocytes and the production of melanin.

The melanocyte is a highly specialised, especially long-lived cell that produces melanin (natural skin pigment/colour) from the amino acid tyrosine. Within the lower layer of the epidermis, there are around 10x more keratinocytes than melanocytes; however, there are still around 1200 melanocytes per mm2 of skin, independent of race. The density of melanocytes in the skin depends mainly on exposure to ultra-violet radiation and factors secreted by keratinocytes and fibroblasts (functional cells found in the dermis, the skin layer beneath the epidermis).

Melanin made in the melanocyte is transferred to basal keratinocytes, with one melanocyte supplying up to 36 keratinocytes. Melanin has many properties that are beneficial to the body including UV light absorption and scattering, free radical scavenging, redox balance and ion storage. The melanocyte also secrets several signal molecules targeting not only keratinocytes but also important immune system skin cells.

1. Langerhans Cell

Modulation of the adaptive immune response

2. Keratinocyte

Primary cellular components of epidermal barrier

3. Melanin Granules

Comprising of melanosomes for ultraviolet protection

4. Melanocyte

The origin of melanin production

5. Dermis

Involvement in the immune response, inflammatory damage and wound healing

Kehilangan melanocytes

Keratinosit dan melanosit diperlukan untuk fungsi kulit dan warna yang normal dan sihat. Gangguan kepada satu atau kedua -dua jenis sel ini boleh mengakibatkan ketidakseimbangan dan lata dalam tekanan dan disfungsi. Tidak seperti keratinosit, pembaharuan semulajadi melanocytes jarang berlaku, dan sebagai akibatnya, apa -apa kehilangan fungsi atau kematian sel tidak hanya membawa kepada tempoh penguraian yang berpanjangan tetapi juga disfungsi kulit biokimia.

Mengenai vitiligo

Vitiligo adalah penyakit autoimun dengan gejala penularan kulit yang sangat jelas. Penghuraian hasil daripada kehilangan melanocytes. Sel Langerhans (sel imun) dianggap memainkan peranan imunologi utama dalam vitiligo (21). Ketidakseimbangan dalam interaksi normal antara keratinosit, melanocytes, dan sel -sel Langerhans dianggap memulakan depigmentasi.

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Patogenesis vitiligo

Adalah diketahui bahawa banyak laluan biokimia semulajadi terganggu apabila vitiligo didiagnosis, termasuk

ketidakseimbangan redoks,
keradangan dan
disfungsi imun

Dalam sesetengah kes, ini disertai dengan tambahan kepada kemasukan sel Langerhans (24), yang dianggap terlibat dalam penyebaran aktif vitiligo (19).

Mengenai Vitiligo Organik

Like other modern, pharmaceutical preparations, this medicine and its active ingredients are backed by science, including several human clinical trials.

Unlike some other products, it’s been designed to provide a wide-ranging and multifaceted approach to addressing several different, key aspects of the disease including

Suppressing immune cells(25) thought to be active in spreading vitiligo within the skin(30), and
Quenching excess hydrogen peroxide, a by-product of melanin production that contributes to melanocyte death, and
Promoting the growth of melanocytes and
Stimulating melanin production

These combined activities can help to normalise skin biology and to restore normal, healthy pigmentation

Mekanisme kerja bahan aktif

Setiap bahan aktif mempunyai aktiviti yang berbeza, setiap penargetan hasil pelengkap, memberikan pendekatan yang komprehensif untuk menormalkan fungsi kulit dan pigmentasi.

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

Purified forms of this substance are used as part of conventional photochemotherapy (30).
Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
Importantly, it suppresses the Langerhans cells(25).

Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)

limiting cellular damage and decline by quenching reactive oxygen species;
suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
promoting melanin production and
normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).

Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
Promoting the renewal and development of melanocytes, and for stimulating melanin production and
Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..

The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

It has potent antioxidant effects that help to suppress oxidative stress, and
It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.

A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.

An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.

As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil

Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

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Cullen Corylifolium

Purified forms of this substance are used as part of conventional photochemotherapy (30).
Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
Importantly, it suppresses the Langerhans cells(25).

Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)

limiting cellular damage and decline by quenching reactive oxygen species;
suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
promoting melanin production and
normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Berberis vulgaris

Berberis Vulgaris

Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
Promoting the renewal and development of melanocytes, and for stimulating melanin production and
Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..

The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

It has potent antioxidant effects that help to suppress oxidative stress, and
It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.

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Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

Studies show that the antioxidant components of virgin coconut oil

Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Mengapa cuba Vitiligo Organics?

Vitiligo Organics is well known and trusted vitiligo medicine for over a decade. It is listed in the Australian Register of Therapeutic Goods, having satisfied the requirements for purity, quality, safety, and effectiveness. It is manufactured in TGA licensed facility, by qualified and authorised professionals, using ingredients and processes that have been validated and verified. TGA is a similar regulatory authority in Australia as FDA in the United States.

Every aspect of the Manufacturing and Quality Control is carefully managed, from the chemical fingerprint identity verification of all the herbs, through to the manufacture, product testing and packaging processes. Following the latest science, we source every ingredient for the highest possible quality and efficacy. No compromise to the quality and unique scientific formulation makes Vitiligo Organics extremely effective.

Vitiligo Organics is one of very few, authentic medicines that takes a comprehensive, multifaceted science-based approach remedying the symptoms of vitiligo; and readdressing what are considered to be some of the underlying causes and consequences of the disease. We don’t claim to have all the answers, but we sincerely believe that this product can and does help reversing the symptoms of vitiligo; and that both tradition and modern scientific evidence support its use.

Kedai VO

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Bibliografi

Ali Current Challenges in Understanding the Story of Skin Pigmentation — Bridging the Morpho-Anatomical and Functional Aspects of Mammalian Melanocytes Chapter 10 Muscle Cell and Tissue doi.org/10.5772/60714
Ali (2011) In vitro responses of fish melanophores to lyophilized extracts of Psoralea corylifolia seeds and pure psoralen, Pharmaceutical Biology, 2011; 49(4): 422–427
Ali (2015) Understanding the ultrastructural aspects of berberine-induced skin-darkening activity in the toad, Bufo melanostictus, melanophores J Microsc Ultrastruct. 2015 Oct-Dec; 3(4): 210–219.
Aljabre Dermatological effects of Nigella Sativa, Journal of Dermatology & Dermatologic surgery 19
Arayne et al; The Berberis Story: Berberis vulgaris in Therapeutics Pak. J. Pharm. Sci., 2007, Vol.20(1), 83-92
Armin Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects Planta Med 2016; 82: 8–16
Bhat Alteration in anti-oxidant defense system and protein expression in response to varied concentrations of EMS in Psoralea corylifolia, Acta Physiol Plant (2015) 37:1707
Bradley British Herbal Compendium Volume A handbook of scientific information on widely used plant drugs,2006 British Herbal Medicine Association ISBN 0 903032 12 0 BVT16

Chaudhuri Bakuchiol: A Retinol-Like Functional Compound, Modulating Multiple Retinol and Non-Retinol Targets, Chapter 1 Cosmeceuticals and Active Cosmetics Third Edition, 2016, ISBN 978-1-4822-1417-8

Chung The effects of Psoralea fructus fruit extract on Melanin Synthesis of B16 Melanoma Cells, J Korean Oriental Medicine; 2005

Gao Principles of Differentiation and Prescription for Vitiligo in Traditional Chinese Medicine Based on a Literature Investigation. Integr Med Int 2015;2:149–156

Gianfaldoni Herbal Compounds for the Treatment of Vitiligo: A Review Global Dermatology-2 Maced J Med Sci. 2018 Jan 25; 6(1):203-207.

Ghorbanibirgani Comparing Nigella sativa Oil and Fish Oil in Treatment of Vitiligo Iran Red Crescent Med J. 2014 June; 16(6): e4515.

Hann Vitiligo A Monograph on the basic and Clinical Science, ISBN 0-632-05071-3, 2000

Illam Polyphenols of Virgin coconut oil prevent pro-oxidant mediated cell death Toxicology Mechanisms and Methods, 2017

Imanshahisi Berberis vulgaris and its Active Constituent, Berberine Phytother. Res. 22, 999–1012 (2008)

Kalmarzi Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds Oxidative Medicine and Cellular Longevity Volume 2019,

Leighton European Barberry (Monograph) Natural Medicines Comprehensive Database, 2021 Therapeutic Research Center B.01

Lotti (Ed) Vitiligo Problems and Solutions, 2004 Marcel Dekker Inc ISBN 0-8247-435-9 VS.06

Majdalawieh Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. International Immunopharmacology 28 (2015)

Manga & Arowojolu Vitiligo, Reference Module in Biomedical Research 2010 Elsevier

Nevin Effect of Topical Application of Virgin Coconut Oil on Skin Components and Antioxidant Status during Dermal Wound Healing in Young Rats Skin Pharmacol Physiol 2010;23:290–297

O’Neil (Ed) The Merek Index, An Encyclopedia of Chemicals, Drugs and Biologicals (15th Edition), 2013 The Royal Society of Chemistry ISBN: 978-1-849-670-1

Pei Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula Journal of Ethnopharmacology 190 (2016) 272–287

Picardo & Taïeb (Eds.) Vitiligo, 2010 Springer Heidelberg ISBN: 978-3-540-69360-4

Ramawat Bioactive Molecules and Medicinal Plants 2008 ISBN 978-3-540-74600-3

Sarac Effectiveness of topical Nigella sativa for vitiligo treatment Dermatologic Therapy. 2019

Sharil-Rad et al Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action, Frontiers in Pharmacology October 2020

Sintahphuak Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil Pharmaceutical Biology, 2010; 48(2): 151–157 Informa healthcare

Sivamani Cosmeceuticals and Active Cosmetics Third Edition 2016 CRC Press, Taylor & Francis Group, LLC ISBN: 978-1-4822-1417-8

Sweetman (Ed) Martindale The Complete Drug Reference (36th Edn) 2009 Pharmaceutical Press ISBN 978 0 85369 840 1

Tahir Current remedies for vitiligo Autoimmunity Reviews 9 (2010) 516–520

Verallo-Rowell Novel Antibacterial and Emollient Effects of Coconut and Virgin Olive Oils in Adult Atopic Dermatitis Dermatitis, Vol 19, No 6

Wang; Metabolic Activation of Pyrrolizidine Alkaloids Leading to Phototoxicity and Photogenotoxicity in Human HaCaT Keratinocytes Journal of Environmental Science and Health, Part C, 32:362–384, 2014

World Health Organisation Monographs on selected medicinal plants Volume 4 ISBN 978 92 4 154705 5, 2009

Xu A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo Evidence-Based Complementary and Alternative Medicine Volume 2019,

Yoon Complementary and Alternative Medicine for Vitiligo (Chapter 10) Vitiligo – Management and Therapy, 2011 ISBN: 978-953-307-731-4,

Zakaria In vivo Antinociceptive and Anti-inflammatory Activities of Dried and Fermented Processed Virgin Coconut Oil Karger Med Princ Pract 2011;20:231–236

Zalid Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease, Int J Mol Biol Open Access 2017.

Zou Eucommia and fructus psoraleae promote the proliferation of osteoblasts cultured in vitro: an experimental study, Journal of Hainan Medical University 2017; 23(12): 1-3