素材と研究

白斑患者の大多数は、白斑に対してできることは何もないと考えている。
最もよくある質問は、"この製品はどのように機能するのですか？"です。
Vitiligo Organics がどのように作用するのかを理解するためには を理解する必要があります。 Vitiligo Organicsがどのように作用するのかを理解するためには、白斑によって皮膚がどのような影響を受けるのかを理解すること、そして薬効成分の特性を理解することが必要です。

皮膚の構造と機能

臓器としての皮膚
臓器としての皮膚 皮膚は複雑な臓器であり、物理的な保護を提供するだけでなく、体温調節、触覚、紫外線の吸収（反射）、免疫システムにおける防御の第一線として機能する。

皮膚は複雑な臓器である。健康な肌では、これらすべての要素がまとまって働き、私たちを守ってくれる。
機能的皮膚細胞
皮膚の一番外側の層は表皮と呼ばれ、いくつかの層からなり、
  • ケラチノサイト（バリア細胞）、
  • メラノサイト（色素細胞）、
  • ランゲルハンス細胞（免疫細胞）、
  • メルケル細胞（感覚細胞）の4つの主要な細胞タイプを含んでいる、
  • ランゲルハンス細胞（免疫細胞）、
  • メルケル細胞（感覚細胞）である。
Functional Skin Cells
皮膚細胞はデスモソームによってつなぎ合わされ、ケラトヒアリンとラメラ顆粒によって保護され、強化されている。
Keratinocytes, Melanocytes & Melanin
ケラチノサイトは細胞集団の90％を占める。 細胞である。ケラチノサイトは表皮の最下層または基底層から発生し、約4週間かけて上方に移動する。 ケラチノサイトは表皮の最下層、基底層から発生し、約4週間かけて上方に移動し、表皮の外側（角質層）に達し、そこで剥がれ落ちる。 そこで剥がれ落ちる。ケラチノサイトもメラノサイトも ケラチノサイトとメラノサイトはともに、メラノサイトの増殖とメラニン産生を制御する重要なタンパク質を産生する。 メラノサイトの成長、増殖、およびメラニンの産生を制御する重要なタンパク質を産生する。
メラノサイトは高度に特殊化された細胞である、 チロシンというアミノ酸からメラニン（天然 色素）を産生する。表皮の下層には 表皮の下層では、ケラチノサイトの数はメラノサイトの 約10倍である； しかし、それでも皮膚1mm2あたり約1200個のメラノサイトが存在する、 人種は関係ない。皮膚のメラノサイトの密度は、主に紫外線への曝露と、メラノサイトから分泌される因子に左右される。 皮膚のメラノサイトの密度は、主に紫外線への曝露と、ケラチノサイトと線維芽細胞（真皮にある機能細胞）から分泌される因子に左右される。 ケラチノサイトと線維芽細胞（表皮の下の皮膚層である真皮にある機能細胞）から分泌される因子に左右される。 表皮の下にある真皮層にある機能細胞）から分泌される因子に左右される。
メラノサイトで作られたメラニンは、基底ケラチノサイトに移行する。 メラノサイトで作られたメラニンは基底ケラチノサイトに移行し、1個のメラノサイトから最大36個のケラチノサイトに供給される。 のケラチノサイトに供給される。メラニンには、紫外線の吸収や散乱、フリーラジカル除去など、身体に有益な多くの特性がある。 紫外線の吸収と散乱、フリーラジカル 消去、酸化還元バランス、イオン貯蔵など、身体に有益な多くの性質を持っている。メラノサイトはまた、ケラチノサイトだけでなく シグナル分子を分泌している。 重要な免疫系皮膚細胞も標的とする。
Keratinocytes Melanocytes Melanin

1.ランゲルハンス細胞

適応免疫応答の調節

2.ケラチノサイト

表皮バリアの主要細胞成分

3.メラニン顆粒

メラノソームからなる紫外線防御剤

4.メラノサイト

メラニン生成の起源

5.真皮

免疫反応、炎症性損傷、創傷治癒への関与
Loss of Melanocytes
ケラチノサイトとメラノサイトは、正常で健康な肌 機能と色に必要である。これらの細胞タイプの一方または両方が破壊されると、バランスが崩れ、ストレスや機能障害が連鎖する。 バランスが崩れ、ストレスや機能障害が連鎖する。ケラチノサイトとは異なり ケラチノサイトとは異なり、メラノサイトの自然更新はまれである。 その結果、機能低下や細胞死が起こると、色素脱失が長期化するだけでなく、生化学的な皮膚変化が起こる。 色素脱失の長期化だけでなく、生化学的な皮膚機能障害にもつながる。 機能障害につながる。
Loss Of Melanocytes

白斑について

白斑は、皮膚の色素脱失という非常に目に見える症状を伴う自己免疫疾患である。 色素脱失である。色素脱失はメラノサイトの減少に起因する。 ランゲルハンス細胞（免疫細胞）は、白斑において免疫学的に重要な役割を果たしていると考えられている(21) 白斑において免疫学的な役割を果たしていると考えられている(21)。ケラチノサイトとメラノサイト、ランゲルハンス細胞の正常な相互作用の不均衡 ケラチノサイト、メラノサイト、ランゲルハンス細胞間の正常な相互作用の不均衡が、色素脱失を引き起こすと考えられている。 色素脱失を引き起こすと考えられている。
About Vitiligo
Vitiligo Pathogenesis

尋常性白斑と診断された場合、

以下を含む多くの自然な生化学的経路が障害されることが知られている。
  • 酸化還元不均衡、
  • 炎症、
  • 免疫機能障害
を含む。 場合によっては、ランゲルハンス細胞(24)の流入に加えて ランゲルハンス細胞(24)の流入を伴う場合もある。 尋常性白斑(19)に関与していると考えられている。
Vitiligo Pathogenesis

Vitiligo Organicsについて

他の製剤と同様 他の近代的な医薬品製剤と同様に、この薬とその有効成分は この薬と有効成分は、いくつかのヒト臨床試験を含む科学的裏付けがある。 科学的裏付けがある。

他のいくつかの製品とは異なり、この製品は、幅広い多面的なアプローチを提供するように設計されています。 幅広い多面的なアプローチを提供するように設計されています。 このような場合、この製品は、そのような患者をサポートするために設計されたものです。
  • 皮膚内で白斑を広げるのに活性があると考えられている免疫細胞(25)を抑制し(30)、
  • メラニン産生の副産物であり、メラノサイトの死滅に寄与する過剰な過酸化水素を消す、
  • メラノサイトの成長を促進し、
  • メラニン産生を刺激する

これらの複合的な作用により、皮膚の生物学を正常化し、正常で健康的な色素沈着を回復させることができる。

有効成分の作用メカニズム

各有効成分にはそれぞれ異なる作用があり、それぞれが補完的な結果を目標にすることで、肌機能と色素沈着を正常化するための包括的なアプローチを提供する。
Cullen Corylifolium
Berberis Vulgaris
Nigella Sativa Seeds
Virgin Coconut Oil
Vitiligo Organics Natural Ingredients - Cullen Corylifolium Whole Plant

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

  • Purified forms of this substance are used as part of conventional photochemotherapy (30).
  • Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
  • Importantly, it suppresses the Langerhans cells(25).
Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)
  • limiting cellular damage and decline by quenching reactive oxygen species;
  • suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
  • promoting melanin production and
  • normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Vitiligo Organics Natural Ingredients - Berberis Vulgaris Root Bark

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).
Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.
Vitiligo Organics Natural Ingredients - Nigella Vulgaris Root Bark

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.
A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.
An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.
As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.
Vitiligo Organics Natural Ingredients - Certified Organic Coconut Oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil
  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Cullen Corylifolium
cullen-corylifolium-in

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

  • Purified forms of this substance are used as part of conventional photochemotherapy (30).
  • Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
  • Importantly, it suppresses the Langerhans cells(25).
Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)
  • limiting cellular damage and decline by quenching reactive oxygen species;
  • suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
  • promoting melanin production and
  • normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Berberis Vulgaris
Berberis-Vulgaris-root

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).

Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.
Nigella Sativa Seeds
Nigella-seeds

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.

A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.

An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.

As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.

Virgin Coconut Oil
coconut-oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil

  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Vitiligo Organics

Why Try Vitiligo Organics?

Vitiligo Organics is well known and trusted vitiligo medicine for over a decade. It is listed in the Australian Register of Therapeutic Goods, having satisfied the requirements for purity, quality, safety, and effectiveness. It is manufactured in TGA licensed facility, by qualified and authorised professionals, using ingredients and processes that have been validated and verified. TGA is a similar regulatory authority in Australia as FDA in the United States.
Every aspect of the Manufacturing and Quality Control is carefully managed, from the chemical fingerprint identity verification of all the herbs, through to the manufacture, product testing and packaging processes. Following the latest science, we source every ingredient for the highest possible quality and efficacy. No compromise to the quality and unique scientific formulation makes Vitiligo Organics extremely effective.
Vitiligo Organics is one of very few, authentic medicines that takes a comprehensive, multifaceted science-based approach remedying the symptoms of vitiligo; and readdressing what are considered to be some of the underlying causes and consequences of the disease. We don’t claim to have all the answers, but we sincerely believe that this product can and does help reversing the symptoms of vitiligo; and that both tradition and modern scientific evidence support its use.
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