Ingredientes & Investigación

La mayoría de las personas que padecen vitíligo creen que no se puede hacer nada contra esta enfermedad.
Nuestra pregunta más frecuente es "¿Cómo funciona este producto?".
Entender cómo funciona Vitiligo Organics requiere una apreciación de cómo la piel se ve afectada por el vitíligo, así como los atributos de los ingredientes medicinales tanto de forma independiente como en combinación.

Estructura y función de la piel

La piel como órgano
La piel como órgano  La piel es un órgano complejo que proporciona protección física, además de controlar la temperatura, permitir la sensación táctil, absorber (y reflejar) la luz ultravioleta y actuar como primera línea de defensa del sistema inmunitario.

La piel es un órgano complejo, Nuestra piel está dividida en varias capas, cada una de las cuales incluye sus propios elementos funcionales. En una piel sana, todos estos elementos trabajan cohesionados para protegernos.
Células cutáneas funcionales
La capa más externa de la piel se denomina epidermis, consta de varias capas y contiene cuatro tipos principales de células
  • Queratinocitos (Células de barrera),
  • Melanocitos (Células pigmentarias),
  • células de Langerhans (células inmunitarias), y
  • células de Merkel (sensoriales).
Functional Skin Cells
Las células de la piel se mantienen unidas por desmosomas, y las células están protegidas y fortificadas por queratohialina y gránulos laminares.
Keratinocytes, Melanocytes & Melanin
Los queratinocitos constituyen ~ el 90% de la población de células. Los queratinocitos se desarrollan a partir de la capa inferior o basal de la epidermis y luego migran hacia arriba durante un periodo de unas cuatro semanas hasta la superficie externa (estrato córneo), donde se desprenden. Tanto los queratinocitos como los melanocitos producen proteínas clave que regulan el crecimiento y multiplicación de los melanocitos y la producción de melanina.
El melanocito es una célula altamente especializada, especialmente longeva que produce melanina (pigmento/color natural de la piel) a partir del aminoácido tirosina. pigmento/color natural de la piel) a partir del aminoácido tirosina. En la capa inferior de la de la epidermis, hay unas 10 veces más queratinocitos que melanocitos; Sin embargo, sigue habiendo unos 1200 melanocitos por mm2 de piel, independientemente de la raza. La densidad de melanocitos en la piel depende de la exposición a la radiación ultravioleta y de los factores secretados por los queratinocitos y fibroblastos (células funcionales que se encuentran en la dermis, la capa cutánea situada bajo la epidermis).
La melanina producida en el melanocito se transfiere a los queratinocitos basales. queratinocitos basales, y un melanocito abastece hasta 36 queratinocitos. La melanina tiene muchas propiedades beneficiosas para el cuerpo, como la absorción y dispersión de la luz ultravioleta libres, el equilibrio redox y el almacenamiento de iones. El melanocito también secreta varias moléculas de señalización dirigidas no sólo a los queratinocitos, sino también a importantes células cutáneas del sistema inmunitario.
Keratinocytes Melanocytes Melanin

1. Células de Langerhans

Modulación de la respuesta inmunitaria adaptativa

2. Queratinocitos

Componentes celulares primarios de la barrera epidérmica

3. Gránulos de melanina

Compuesto de melanosomas para la protección ultravioleta

4. Melanocitos

El origen de la producción de melanina

5. Dermis

Participación en la respuesta inmunitaria, el daño inflamatorio y la cicatrización de heridas
Loss of Melanocytes
Los queratinocitos y los melanocitos son necesarios para que la piel y el color de la piel. La alteración de uno o ambos tipos de células puede provocar un desequilibrio y una cascada de tensiones y disfunciones. A diferencia de queratinocitos, la renovación natural de los melanocitos es rara y, como consecuencia, cualquier pérdida de función o muerte celular no sólo provoca períodos prolongados de despigmentación, sino también una disfunción bioquímica de la piel.
Loss Of Melanocytes

Acerca del vitíligo

El vitíligo es una enfermedad autoinmune con síntomas muy visibles de despigmentación cutánea. despigmentación de la piel. La despigmentación es el resultado de la pérdida de melanocitos. Se cree que las células de Langerhans (células inmunitarias) desempeñan un importante papel inmunológico en el vitíligo(21). inmunológico en el vitíligo(21). Se cree que el desequilibrio en las interacciones normales entre queratinocitos, melanocitos y células de Langerhans. iniciar la despigmentación.
About Vitiligo
Vitiligo Pathogenesis

Se sabe que una multitud de vías bioquímicas naturales se interrumpen cuando se diagnostica vitíligo, incluyendo

  • desequilibrio redox,
  • inflamación y
  • disfunción inmunitaria
. En algunos casos, esto se acompaña además de una afluencia de células de Langerhans(24), que se cree que intervienen en la propagación activa vitíligo(19).
Vitiligo Pathogenesis

Acerca de Vitiligo Organics

Al igual que otros preparados farmacéuticos modernos, este medicamento y sus principios activos ingredientes activos están respaldados por la ciencia, incluyendo varios en humanos.

A diferencia de otros productos, ha sido diseñado para proporcionar un enfoque amplio y multifacético para abordar varios aspectos diferentes y clave de la enfermedad, incluyendo.
  • Suprimiendo las células inmunitarias(25) que se cree que son activas en la propagación del vitíligo dentro de la piel(30), y
  • Apagando el exceso de peróxido de hidrógeno, un subproducto de la producción de melanina que contribuye a la muerte de los melanocitos, y
  • Promover el crecimiento de los melanocitos y
  • Estimular la producción de melanina

Estas actividades combinadas pueden ayudar a normalizar la biología de la piel y a restaurar una pigmentación normal y sana.

Mecanismo de acción de los principios activos

Cada uno de los ingredientes activos tiene actividades diferentes, cada una dirigida a resultados complementarios, proporcionando un enfoque integral para normalizar la función de la piel y la pigmentación.
Cullen Corylifolium
Berberis Vulgaris
Nigella Sativa Seeds
Virgin Coconut Oil
Vitiligo Organics Natural Ingredients - Cullen Corylifolium Whole Plant

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

  • Purified forms of this substance are used as part of conventional photochemotherapy (30).
  • Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
  • Importantly, it suppresses the Langerhans cells(25).
Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)
  • limiting cellular damage and decline by quenching reactive oxygen species;
  • suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
  • promoting melanin production and
  • normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Vitiligo Organics Natural Ingredients - Berberis Vulgaris Root Bark

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).
Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.
Vitiligo Organics Natural Ingredients - Nigella Vulgaris Root Bark

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.
A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.
An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.
As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.
Vitiligo Organics Natural Ingredients - Certified Organic Coconut Oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil
  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Cullen Corylifolium
cullen-corylifolium-in

Cullen Corylifolium

Psoralen is the principal bioactive component in the dried fruits of Cullen Corylifolium. Medical professionals will recognise this substance as being the base of some of the most effective pharmacological interventions for vitiligo (21).

  • Purified forms of this substance are used as part of conventional photochemotherapy (30).
  • Psoralen has a temporary photo-sensitising effect(23), promoting melanin dispersal(2) and increasing the number of melanocytes(24) and
  • Importantly, it suppresses the Langerhans cells(25).
Psoralen, like many other biologically active substances, also influences a number of biochemical processes. Its well-characterised actions include(28)
  • limiting cellular damage and decline by quenching reactive oxygen species;
  • suppressing inflammation by interacting with pro-inflammatory cytokines and suppressing inflammation signalling processes, and
  • promoting melanin production and
  • normalising immune responses(29)

These attributes alone are often deemed to be sufficient for professional management of vitiligo; this ingredient’s activity is complemented by other, similarly powerful substances.

Berberis Vulgaris
Berberis-Vulgaris-root

Berberis Vulgaris

Barberry root (Berberis vulgaris) has been used for millennia(5) and across many different traditional medicine paradigms as a remedy for vitiligo. Modern science is now beginning to decipher how Barberry root bark influences skin health and promotes a more normal function. The root bark contains naturally occurring berberine at concentrations of up to ~7-12%(8).

Berberine is a potent phytochemical that has a wide range of therapeutic benefits(16) including immune-modulating and anti-inflammatory activities(34).

Most specifically it appears to have a role in

  • Neutralising the hydrogen peroxide that contributes to the destruction of melanocytes, produced both by keratinocytes’ oxidative stress(18) and as a by-product of melanin production(29) and
  • Promoting the renewal and development of melanocytes, and for stimulating melanin production and
  • Stimulating tyrosinase, a key enzyme required to transform tyrosine into melanin..
The biochemical pathways identified for Berberine’s activity are different to those exploited by Psoralen; providing a complementary therapeutic effect.
Nigella Sativa Seeds
Nigella-seeds

Nigella Sativa Seeds

Thymoquinone is widely regarded as being the biologically active component of Nigella Sativa.

Thymoquinone is likely to have a dual action in the remediation of vitiligo

  • It has potent antioxidant effects that help to suppress oxidative stress, and
  • It can trigger a multi-step, biochemical pathway, that has a stimulatory effect on melanin production, as has been demonstrated in animals.

A recent human-clinical trial(27) conducted in 2019 demonstrated that a cream containing Nigella sativa resulted in statically significant re-pigmentation in the hands, face and genital region of 47 men and women with vitiligo after 6 months of use, and was considered to be especially suitable for use on delicate skin.

An earlier double-blind randomised human clinical trial(13) compared the effects of Nigella sativa and Fish Oil in resolving the symptoms of Vitiligo. Nigella oil was found to be more effective, with the Vitiligo Area Scoring Index reducing from 4.98 to 3.75, with pronounced improvements in the upper extremities, trunk, head and neck after 6 months of use.

As is the case of Psoralen and Berberine; Thymoquinone utilises different inter and intra-cellular processes and different biochemistry in effecting its antioxidant and stimulatory effects. The combination of three distinct types of pharmacologically active substances in this natural medicine provides a sound basis for re-establishing balance across a wide range of processes that are dysfunctional in vitiligo affected skin.

Virgin Coconut Oil
coconut-oil

Virgin Coconut Oil

Unlike the other actives that specifically target the metabolic pathways directly associated with vitiligo, virgin coconut oil serves to nurture, condition and normalise overall skin health.

The oil has emollient, occlusive and rehydrating properties. This ensures that the biologically active components of Cullen (Psoralea) Corylifolium, Berberis Vulgaris and Nigella Sativa are maintained close to the skin, and presented in an environment where there is sufficient biologically available moisture to facilitate their uptake and utilisation.

Monolaurin, a derivative of the coconut oil constituent lauric acid, demonstrates antimicrobial activity against some dermal pathogens, such as Staphylococcus aureus, Staphylococcus epidermidis, and Candida albicans(18). A clinical trial published in 2008(32) demonstrated that compared to Virgin olive oil, virgin coconut oil reduced skin infection and inflammation after 4 weeks of application.

Studies show that the antioxidant components of virgin coconut oil

  • Promote enhanced skin cell renewal(21); histopathological examination demonstrates an increase in fibroblast proliferation and neovascularization compared to controls, and
  • Are effective at reducing hydrogen-peroxide mitigated cell death (15).

Other studies demonstrate that it has anti-inflammatory, analgesic, and antipyretic activities; and helps to reduce acute(37) and chronic inflammation(29). A randomised double, blind clinical trial showed that topical application of virgin coconut substantially improved skin health and barrier function in children with stressed and inflamed skin.

Vitiligo Organics

¿Por qué probar Vitiligo Organics?

Vitíligo Organics es bien conocido y de confianza vitiligo medicina durante más de una década. Está inscrito en el Registro Australiano de Productos Terapéuticos, habiendo requisitos de pureza, calidad, seguridad y eficacia. eficacia. Se fabrica en instalaciones autorizadas por la TGA, por profesionales cualificados y autorizados. y autorizados, utilizando ingredientes y procesos que han sido han sido validados y verificados. La TGA es una autoridad reguladora similar en Australia como la FDA en Estados Unidos.
Cada aspecto de la fabricación y el control de calidad se gestiona desde la verificación de la identidad química de todas las hierbas todas las hierbas, hasta la fabricación, las pruebas del producto y los y envasado. Siguiendo los últimos avances científicos, seleccionamos cada ingrediente la mayor calidad y eficacia posibles. Sin comprometer la calidad y una formulación científica única hacen que Vitiligo Organics sea extremadamente eficaz.
Vitiligo Organics es una de las pocas medicinas auténticas que adopta un enfoque enfoque integral y multifacético basado en la ciencia que remedia los los síntomas del vitíligo, y aborda de nuevo lo que se consideran algunas de las las causas subyacentes y las consecuencias de la enfermedad. No pretendemos tener todas las respuestas, pero creemos sinceramente que este producto puede puede y ayuda a revertir los síntomas del vitíligo; y que tanto la la tradición y la evidencia científica moderna apoyan su uso.
Tienda VO

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