The majority of vitiligo sufferers believe there is nothing that can be done for vitiligo.
Our most frequently asked question is “How does this product work?”
Understanding how Vitiligo Organics works requires an appreciation of
how the skin is impacted by vitiligo, as well as the attributes of the
medicinal ingredients both independently and in combination.
Ingredients & Research
Skin Structure & Function
The Skin as an Organ
The Skin as an Organ The skin is a complex organ, providing physical protection as well as controlling temperature, permitting touch sensation, absorbing (and reflecting) UV light and acting as the first line of defence in the immune system.
The skin is a complex organ, Our skin is divided into several layers, each including its own functional elements. In healthy skin, all of these elements work cohesively to protect us.
Functional Skin Cells
The outermost layer of the skin is called the epidermis, it consists of several layers and contains four major cell types
- Keratinocytes (Barrier cells),
- Melanocytes (Pigment Cells),
- Langerhans cells (Immune cells), and
- Merkel cells (Sensory).
Skin cells are held together by desmosomes, and the cells are protected and fortified by keratohyalin and lamellar granules.
Keratinocytes, Melanocytes & Melanin
Keratinocytes make up ~ 90% of the population of
cells. Keratinocytes develop from the bottom or basal layer of the
epidermis and then migrate upwards over a period of about four weeks to
the outer surface (stratum corneum) where they are shed. Both
keratinocytes and melanocytes produce key proteins that regulate the
growth, and multiplication of melanocytes and the production of melanin.
The melanocyte is a highly specialised,
especially long-lived cell that produces melanin (natural skin
pigment/colour) from the amino acid tyrosine. Within the lower layer of
the epidermis, there are around 10x more keratinocytes than melanocytes;
however, there are still around 1200 melanocytes per mm2 of skin,
independent of race. The density of melanocytes in the skin depends
mainly on exposure to ultra-violet radiation and factors secreted by
keratinocytes and fibroblasts (functional cells found in the dermis, the
skin layer beneath the epidermis).
Melanin made in the melanocyte is transferred to
basal keratinocytes, with one melanocyte supplying up to 36
keratinocytes. Melanin has many properties that are beneficial to the
body including UV light absorption and scattering, free radical
scavenging, redox balance and ion storage. The melanocyte also secrets
several signal molecules targeting not only keratinocytes but also
important immune system skin cells.
1. Langerhans Cell
Modulation of the adaptive immune response
2. Keratinocyte
Primary cellular components of epidermal barrier
3. Melanin Granules
Comprising of melanosomes for ultraviolet protection
4. Melanocyte
The origin of melanin production
5. Dermis
Involvement in the immune response, inflammatory damage and wound healing
Loss of Melanocytes
Keratinocytes and melanocytes are necessary for normal, healthy skin
function and colour. Disruption to one or both of these cell types can
result in imbalance and a cascade in stresses and dysfunction. Unlike
keratinocytes, the natural renewal of melanocytes is rare, and as a
consequence, any loss in function or cell death leads not only to
prolonged periods of depigmentation but also biochemical skin
dysfunction.
About Vitiligo
Vitiligo is an autoimmune disease with highly visible symptoms of skin
depigmentation. The depigmentation results from melanocytes loss.
Langerhans cells (immune cells) are thought to play a major
immunological role in vitiligo(21). Imbalance in the normal interactions
between keratinocytes, melanocytes, and Langerhans cells is thought to
initiate the depigmentation.
Vitiligo Pathogenesis
It is known that a multitude of natural biochemical pathways are disrupted when vitiligo is diagnosed, including
- redox imbalance,
- inflammation and
- immune dysfunction
About Vitiligo Organics
Like
other modern, pharmaceutical preparations, this medicine and its active
ingredients are backed by science, including several human clinical
trials.
Unlike some other products, it’s been
designed to provide a wide-ranging and multifaceted approach to
addressing several different, key aspects of the disease including.
- Suppressing immune cells(25) thought to be active in spreading vitiligo within the skin(30), and
- Quenching excess hydrogen peroxide, a by-product of melanin production that contributes to melanocyte death, and
- Promoting the growth of melanocytes and
- Stimulating melanin production
Working Mechanism of Active Ingredients
Each of the active ingredients has different activities, each targeting complementary outcomes, providing a comprehensive approach to normalising skin function and pigmentation.
Why Try Vitiligo Organics?
Vitiligo
Organics is well known and trusted vitiligo medicine for over a decade.
It is listed in the Australian Register of Therapeutic Goods, having
satisfied the requirements for purity, quality, safety, and
effectiveness. It is manufactured in TGA licensed facility, by qualified
and authorised professionals, using ingredients and processes that have
been validated and verified. TGA is a similar regulatory authority in
Australia as FDA in the United States.
Every aspect of the Manufacturing and Quality Control is carefully
managed, from the chemical fingerprint identity verification of all the
herbs, through to the manufacture, product testing and packaging
processes. Following the latest science, we source every ingredient for
the highest possible quality and efficacy. No compromise to the quality
and unique scientific formulation makes Vitiligo Organics extremely
effective.
Vitiligo Organics is one of very few, authentic medicines that takes a
comprehensive, multifaceted science-based approach remedying the
symptoms of vitiligo; and readdressing what are considered to be some of
the underlying causes and consequences of the disease. We don’t claim
to have all the answers, but we sincerely believe that this product can
and does help reversing the symptoms of vitiligo; and that both
tradition and modern scientific evidence support its use.
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